Principal Diagnostic Serum Enzymes

Principal Diagnostic Serum Enzymes for Clinical diagnosis

Diagnostic Serum Enzymes:

Certain tissue cells contain characteristic enzymes which enter the blood only when the cells to which they are confined are damaged or destroyed. The presence in the blood of significant quantities of these specific enzymes indicates the probable site of tissue damage.

Enzymes Routinely Measured
Aspartate Amino Transferase (AST)

Serum glutamate- oxaloacetate (SGOT)

Heart and Liver
Alanine Amino Transferase(ALT)

Serum glutamate – Pyruvate Transferase(SGPT)

Heart and Liver

A list of a few enzymes of diagnostic importance-

Principal Serum Enzymes Used in Clinical diagnosis
Amino transferase Aspartate amino transferase (AST or SGOT) Myocardial infarction

Viral Hepatitis

Amylase Acute Pancreatitis
Ceruloplasmin Hepatolenticular Degenertion (Wilson’s disease )
Creatine kinase Muscle disorder and Myocardial infarction
γ – Glutamyl transpeptidase Various liver diseases
Lactate dehydrogenase Myocardial infarction
Lipase Acute pancreatitis
Phosphatase, acid Metastatic carcinoma of the prostate
Phosphatase, alkaline (isozymes) Various bone disorders, obstructive liver diseases

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