Principal Diagnostic Serum Enzymes for Clinical diagnosis

Principal Diagnostic Serum Enzymes for Clinical diagnosis

Diagnostic Serum Enzymes:

Some tissue cells contain distinctive enzymes that only enter the blood when damage or destruction occurs to the cells to which they are restricted. The existence of important amounts of these particular enzymes in the blood shows the likely tissue harm site. By identifying the distinctive enzymes in the serum we can know the possible tissue damage.  Those enzymes are diagnostic serum enzymes

Name of the enzyme Present in
Aspartate Amino Transferase (AST) and Serum glutamate- oxaloacetate (SGOT) Heart and Liver
Alanine Amino Transferase(ALT) and Serum glutamate – Pyruvate Transferase(SGPT) Heart and Liver

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A list of a few important Diagnostic Serum Enzymes-

Serum Enzymes are important for the treatment of many diseases. A list of some important Serum Enzymes is-

Principal Serum Enzymes Used in Clinical diagnosis
Aminotransferase Aspartate aminotransferase (AST or SGOT) Myocardial infarction / Viral Hepatitis
Amylase Acute Pancreatitis
Ceruloplasmin Hepatolenticular Degeneration (Wilson’s disease )
Creatine kinase Muscle disorder and Myocardial infarction
γ – Glutamyl transpeptidase Various liver diseases
Lactate dehydrogenase Myocardial infarction
Lipase Acute pancreatitis
Phosphatase, acid Metastatic carcinoma of the prostate
Alkaline (isozymes), Phosphatase, obstructive liver diseases, Various bone disorders

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